home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Software Vault: The Diamond Collection
/
The Diamond Collection (Software Vault)(Digital Impact).ISO
/
cdr16
/
med9505a.zip
/
M9550077.TXT
< prev
next >
Wrap
Text File
|
1995-03-04
|
2KB
|
31 lines
Document 0077
DOCN M9550077
TI Immunological and virological markers determining progression to AIDS.
DT 9505
AU Schellekens PT; Koot M; Roos MT; Tersmette M; Miedema F; Department of
Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red
Cross Blood Transfusion Service, Amsterdam.
SO Neth J Med. 1994 Dec;45(6):238-43. Unique Identifier : AIDSLINE
MED/95140113
AB Infection with the human immunodeficiency virus (HIV-1) results in a
severe immunodeficiency characterized by a depletion of CD4+ T-helper
cells. Furthermore it is well documented that in asymptomatic persons
the number of CD4+ cells is also a good predictor of progression to
AIDS. However, persons with similar CD4+ cell counts may differ with
regard to clinical progression. For this reason the development of
additional markers predictive of disease progression is of major
clinical importance. In this review three additional progression markers
are discussed: rate of decline of CD4+ cells, T-cell reactivity and HIV
biological phenotype. Besides their usefulness as independent
progression markers they also provide insight into the
immunopathological mechanisms responsible for the final development of
AIDS.
DE Biological Markers *CD4 Lymphocyte Count Disease Progression Human
HIV Infections/DRUG THERAPY/*IMMUNOLOGY *HIV-1/GENETICS Lymphocyte
Transformation Phenotype Predictive Value of Tests Prognosis
Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).